Promotion in Bio- und Chemiewissenschaften
Forschungsschwerpunkte
Innerhalb der Bio- und Chemiewissenschaften gibt es verschiedene Möglichkeiten der Spezialisierung. Folgende Forschungsbereiche lassen sich unter anderem diesem Studienfeld zuordnen.
Biowissenschaften:
- Biochemistry
- Bioinformatics
- Biotechnology
- Cell Biology
- Ecology
- Evolutionary Biology
- Experimental Biology
- Genetics
- Immunology
- Marine Science
- Microbiology & Molecular Biology
- Neuro Science
- Plant Biology
- Stem Cell Research
- Structural Biology
- Zoology
Chemiewissenschaften:
- Advanced Materials Chemistry & Nanoscience
- Analytical & Bioanalytical Chemistry
- Chemical Theory & Computation
- Biological & Medicinal Chemistry
- Energy & Catalysis
- Environmental Chemistry
- Inorganic & Organic Chemistry
- Molecular Design & Synthesis
- Physical & Theoretical Chemistry
- Polymer Chemistry
Dein genaues Forschungsthema kannst du in direkter Absprache mit den potentiellen Supervisor:innen abstimmen. Falls du noch keine feste Vorstellung für dein Thema hast, schau dir gerne einige der aktuell ausgeschriebenen Projekte an.
Auswahl möglicher Forschungsprojekte in Australien
PhD Bio, Chemie
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| University: | University of Adelaide |
| Faculty: | Faculty of Science, Engineering, and Technology |
| Project Start Date: | 01.10.2023 |
| Application Deadline: | 30.06.2023 |
| Supervisor Name: | Dr Danny Wilson, danny.wilson@adelaide.edu.au |
| Location (City/Campus): | North Terrace, Adelaide |
| Project Description: | Malaria blood stage parasites grow and replicate within human red blood cells (RBCs). The repeated cycles of blood-stage parasite multiplication cause malaria disease and >600,000 deaths/yr. RBC entry requires coordinated secretion of antigens from two clubbed shaped rhoptry organelles positioned near the parasites apical tip. This project will characterise cytosolically exposed rhoptry interacting proteins (C-RIPs) that have essential roles in rhoptry biology. Using advanced gene-editing, proteomics and quantitative super-resolution microscopy techniques, the project will characterise the role of C-RIPs and interacting partners in rhoptry mechanobiology during RBC entry and define key structural regions that could be targeted by drugs. |
| Funding Information: | |
| Special Requirements: | Experience in one or more of microbiology, molecular and imaging techniques preferred. Experience in a malaria lab desirable. Demonstrated involvement in data generation and writing of a paper also desirable. |
| Additional Information: | Opportunity to also visit and work in collaborators laboratory in Hamburg for periods of time also possible. |
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| University: | University of Adelaide |
| Faculty: | Faculty of Science, Engineering, and Technology |
| Project Start Date: | 01.07.2023 |
| Application Deadline: | 30.06.2023 |
| Supervisor Name: | Stephen P. Kidd, stephen.kidd@adelaide.edu.au |
| Location (City/Campus): | North Terrace, Adelaide |
| Project Description: | This project will directly build on our recent research which has uniquely shown that different bacterial species adopt a range of cell types to enable long term survival during human infection, such as when causing relapsing bone infections. Specifically, a bacterial sub-population of cells with a reduced metabolic rate but tolerance to antimicrobials can also live inside bone cells and thereby act as a reservoir for relapsing infections. This project will describe the molecular pathways that drive the change from a disease-causing cell population to one that is inactive but then reverts to cause a relapsing disease. |
| Funding Information: | |
| Special Requirements: | Experience in Microbiology, Molecular Biology, Molecular Evolution |
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| University: | University of Adelaide |
| Faculty: | Faculty of Science, Engineering, and Technology |
| Project Start Date: | 01.07.2023 |
| Application Deadline: | 30.06.2023 |
| Supervisor Name: | Phill Cassey, phill.cassey@adelaide.edu.au |
| Location (City/Campus): | North Terrace, Adelaide |
| Project Description: | This project will determine the drivers of establishment for alien species in Antarctica, through the combination of species attributes and location (or site) -level attributes, and the driving processes of human activity. Biosecurity management requires a flexible and dynamic approach to multi-species risk assessment. The likelihood of establishment will be modelled as biophysical processes from: (i) species-level traits, (including life-cycle, species limits, and resource requirements of the species) ii) location and site attributes (including physical and biotic characteristics and iii) human activity (including reliability of transport and other activities that promote increased numbers (propagules)). |
| Funding Information: | |
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| University: | University of Sydney |
| Faculty: | Faculty of Engineering |
| Project Start Date: | 01.03.2023 (later start possible) |
| Application Deadline: | no fix deadline, applications accepted until position is filled |
| Supervisor Name: | A/Prof Arnold Lining Ju - arnold.ju@sydney.edu.au |
| Location (City/Campus): | Sydney / Camperdown |
| Project Description: | The mechanical stimuli generated by body exercise can be transmitted from cortical bone into the deep bone marrow. A mechanosensitive perivascular stem cell niche is recently identified within the bone marrow for osteogenesis and lymphopoiesis. However, the mechanopropagation from compact bone to deep bone marrow vasculature remains elusive in this fundamental mechanobiology field. No experimental system is available yet to directly understand such exercise‐induced mechanopropagation at the bone‐vessel interface. To this end, an integrated computational biomechanics framework to quantitatively evaluate the mechanopropagation capabilities of bone marrow arterioles, arteries, and sinusoids is devised. The 3D geometries of blood vessels are smoothly reconstructed in the presence of vessel wall thickness and intravascular pulse pressure, followed by finite element analysis to thoroughly investigate the mechanical effects of exercise‐induced intravascular vibratory stretching on bone marrow vasculature. The effects of blood pressure and cortical bone bending are also examined. It is concluded that arterioles and arteries are much more efficient in transducing mechanical force than sinusoids due to their higher stiffness. In the future, this in-silico approach could be combined with other clinical imaging modalities for subject/patient‐specific vascular reconstruction and biomechanical analysis, providing large‐scale phenotypic data for personalized mechanobiology discovery. |
| Funding Information: | The Scholarship will provide a stipend allowance equivalent to the University of Sydney’s Research Training Program (RTP) stipend rate for up to 3.5 years. RTP stipend is currently $35,950 AUD/year. The scholarship is available to domestic and international students. |
| Admission Requirements: | To apply, email academic transcript and resume to supervisor A/Prof Arnold Lining Ju - arnold.ju@sydney.edu.au You will have to have: • Academic knowledge in the discipline of biophysics, biomechanics, electrophysiology, cell biology and biochemistry; • Experience of Linux/Unix commanding line (Unix shell) • Capability of using two or more of ANSYS, COMSOL, Abaqus, LabVIEW, Python, AutoCAD, MATLAB and other software. Preferred experience include: • Solid basic knowledge of biology and hands-on experience in PC2 biological laboratory, using flow cytometer, ELISA, Western blots, protein-protein interaction assays, protein/antibody purification and functional characterizations; • Experience in theoretical simulation using and MATLAB or COMSOL, or LabVIEW programming to control equipment and devices. • Capability of independently output processing models and drawings, be capable of CNC programming, use other conventional processing platform equipment to manufacture mechanical parts, and use 3D printers for part manufacturing. • Pre-doctoral track records with publications, conference papers, reports, professional or technical contributions with evidence of independent research ability. • Excellent oral and written communication skills. |
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| University: | University of Sydney |
| Faculty: | Faculty of Engineering |
| Project Start Date: | 01.03.2023 (later start possible) |
| Application Deadline: | no fix deadline; application open until position is filled |
| Supervisor Name: | A/Prof Arnold Lining Ju - arnold.ju@sydney.edu.au |
| Location (City/Campus): | Sydney / Camperdown |
| Project Description: | Clotting and bleeding are two sides of a coin, leading to cardiovascular diseases such as stroke and haemophilia—the No.1 worldwide killer. It has long been recognised that the von Willebrand factor (VWF) is the mechanosensor for primary and secondary haemostasis by interacting with platelets and clotting factor VIII. We have recently discovered a new ‘biomechanical’ prothrombotic mechanism that highlights the remarkable VWF sensitivity to the shear stress of blood flow disturbance. Importantly, we found that the current drugs are often not successful and come with an increased financial burden. |
| Funding Information: | The Scholarship will provide a stipend allowance equivalent to the University of Sydney’s Research Training Program (RTP) stipend rate for up to 3.5 years. RTP stipend is currently $35,950 AUD/year. The scholarship is available to domestic and international students. |
| Admission Requirements: | To apply, email academic transcript and resume to supervisor A/Prof Arnold Lining Ju - arnold.ju@sydney.edu.au You will have: Preferred experience include: |
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| University: | University of Melbourne |
| Faculty: | Medicine, Dentistry and Health Sciences |
| Project Start Date: | negotiable |
| Application Deadline: | ongoing |
| Supervisor Name: | Dr Rachael Moses, e-mail: rachael.moses@unimelb.edu.au |
| Location (City/Campus): | Parkville Precinct |
| Project Description: | Humans heal in a different manner to rodents, so we need to start using more representative wound healing models to replicate the tissue architecture and wound healing cascade observed in human dermal wound healing. This exciting PhD opportunity involves developing a 3D infected chronic wound model, comprised of culturing dermal chronic wound fibroblasts, which are obtained from venous leg ulcers and epidermal keratinocytes in a complex 3D model system, allowing the strong paracrine feedback system to occur between the two cell types, as occurs in the native skin environment. This model will be utilising mostly animal-free-origin products, in a move away from typically animal-derived components used in tissue culture, resulting in reduced ethical implications and reduced variability across experiments, due to batch-to-batch variability associated with animal-derived products. This model will use a synthetic hydrogel (PeptiGel®) from Manchester BIOGEL to replace the typically used Matrigel; this PeptiGel® can be tailored to include additional components, including collagen, laminin and fibronectin. This project involves working within the Sloan/Moses lab at The University of Melbourne, benefitting from their extensive 3D model experience. Dr Moses has been awarded a number of grants and prizes recently to further develop this work, with a strong background in wound healing, in vitro 3D models and novel pharmaceutical screening. Professor Sloan has long standing expertise in developing novel in vitro / ex vivo organ 3D culture model systems for tissue regeneration/engineering and testing novel therapeutic agents, along with advancing the 3Rs in biomedical research and bioengineering. Dr Farrugia has a strong background in biomaterial development and characterisation, and wound healing, including in vitro models, with an additional focus on the development of new therapies. Dr Liam Sharkey is a bacteriologist specialising in antibiotic resistance with a particular focus on Staphylococcus aureus, a common cause of chronic wound infections. He has experience with in vitro models of S. aureus biofilm formation and the genetic manipulation of clinical S. aureus strains. This project benefits from collaboration with industrial partners assessing novel pharmaceuticals on these models; these natural pharmaceuticals have previously been assessed by Dr Moses through a variety of other 2D wound healing studies. This project will involve a variety of laboratory-based techniques including tissue culture, 3D models, bacteriology, histology, immunostaining, H&E staining, confocal imaging, translational research, bioinformatics, biostatistics, research management, oral presentation skills, and scientific writing skills. |
| Funding Information: | RTP scholarships are available to domestic and overseas students enrolled in an accredited HDR course at an Australian HEP. More information |
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| University: | University of Adelaide |
| Faculty: | Faculty of Science, Engineering and Technology |
| Project Start Date: | 01.09.2023 |
| Application Deadline: | 30.06.2023 |
| Supervisor Name: | Dr Stijn Glorie, stijn.glorie@adelaide.edu.au |
| Location (City/Campus): | North Terrace, Adelaide |
| Project Description: | This project will apply a range of revolutionary in-situ dating methods (Lu-Hf, Re-Os), which were recently developed at the University of Adelaide, to decipher the timing of hydrothermal alteration and mineralisation in the world-class Olympic Province in South Australia. The development of large iron-oxide copper-gold deposits in this area was a staged process, with an initial event in the early Mesoproterozoic and at least one `upgrading` event in the late Neoproterozoic-Cambrian. The latter event induced fluid flow that might have transported metals from the fertile IOCG basement towards strataboud deposits. The project will assess this temportal link, which will have great implications for future mineral exploration endeavours. |
| Funding Information: | |
| Additional Information: | More info on the novel dating methods can be found in: www.sciencedirect.com/science/article/pii/S0009254121002436 onlinelibrary.wiley.com/doi/full/10.1111/ter.12580 |
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| University: | University of Adelaide |
| Faculty: | Faculty of Science, Engineering and Technology |
| Project Start Date: | 01.08.2023 |
| Application Deadline: | 30.06.2023 |
| Supervisor Name: | Shervin Kabiri, shervin.kabiri@adelaide.edu.au |
| Location (City/Campus): | North Terrace, Adelaide |
| Project Description: | Australia is faced with a big contamination problem relating to chemicals used in firefighting foams, called per- and poly-fluoroalkyl substances or PFAS. PFAS are a large group of chemicals, with over 5000 different species. Their complexity has posed a challenge with existing remediation approaches based on sorbents, with varying success achieved for different PFAS species. For example, current sorbents available in the market cannot effectively immobilise short-chain PFAS.This project aims to develop remediation materials that will be effective for a wider range of PFAS and allow tailored solutions for PFAS immobilisation in soil. This project will assist the PhD student to develop skills in material and soil science, environmental chemistry, analytical techniques and soil management. It also provides an opportunity for the student to work with the industry. |
| Funding Information: | |
| Special Requirements: | The applicant should have good track record of publication. |
| Additional Information: | The successful student will be located at the University of Adelaide’s Waite Campus, working at CSIROs research facility as well as the School of Agriculture. The in-business component of the degree will be conducted at Rembind’s Head Office (2 Ann Nelson Drive, Thebarton SA 5031), but will also involve some interstate travel to remediation projects and manufacturing facilities. |
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| University: | University of Adelaide |
| Faculty: | Faculty of Science, Engineering and Technology |
| Project Start Date: | 01.08.2023 |
| Application Deadline: | 30.06.2023 |
| Supervisor Name: | Cassandra Collins, cassandra.collins@adelaide.edu.au; co-supervisor: Shashi Goonetilleke, shashi.goonetilleke@adelaide.edu.au |
| Location (City/Campus): | North Terrace, Adelaide |
| Project Description: | Sweet kernel in almond has been found to be a heterozygous trait and the bitter kernel to be recessive. Usually, about 25% of the progeny in the Australian almond breeding program have bitter kernels. Presently, plants with bitter almonds will be discarded once they are found to be bitter after 3-4 years in the orchards. Therefore, sweet almonds remain a major breeding target in almond breeding. The gene encodes the sweetness in almond belongs to linkage group five, however, the precise location is still unknown. The broad objective of this project is to identify the genomic regions that affect bitter kernels and evaluate the potential of CRISPR/Cas9 mediated technologies to eliminate the bitterness in almond kernels. |
| Funding Information: | |
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| University: | University of Adelaide |
| Faculty: | Faculty of Science, Engineering and Technology |
| Project Start Date: | 01.08.2023 |
| Application Deadline: | 30.06.2023 |
| Supervisor Name: | Dr Stephanie Watts-Fawkes, stephanie.watts-fawkes@adelaide.edu.au |
| Location (City/Campus): | North Terrace, Adelaide |
| Project Description: | This project will investigate the effects of beneficial mycorrhizal fungi on crop nutrition. The mycorrhizal pathway of phosphorus uptake is important for plants, but may lead to increased accumulation of the anti-nutrient compound phytate in grains and pulses. This project will uncover how mycorrhizal fungi affect phytate accumulation in the edible portion of crops, and how this modifies the bioavailability of micronutrients such as zinc and iron for human consumption. The PhD candidate will inoculate plants with mycorrhizal fungi and grow them until maturity. The resulting grain samples will be analysed for bioavailability and bioaccessibility of Zn and Fe. |
| Funding Information: | |
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| University: | University of Adelaide |
| Faculty: | Faculty of Science, Engineering and Technology |
| Project Start Date: | 01.08.2023 |
| Application Deadline: | 30.06.2023 |
| Supervisor Name: | Matthew Gilliham, matthew.gilliham@adelaide.edu.au and Jenny Mortimer, jenny.mortimer@adelaide.edu.au |
| Location (City/Campus): | North Terrace, Adelaide |
| Project Description: | This project will re-wire plants to optimise their growth in controlled conditions on Earth and in Space. By 2028, humans will have returned to the moon as a precursor to crewed Mars missions but key challenges for mission planners still exist, including: Nutritious, varied foods to sustain physical and mental well-being for humans during long-term Space habitation; and, technology to provide on-demand generation of resources such as pharmaceuticals and construction materials. Space habitation amplifies the multi-faceted sustainability challenges we face in food and biomaterial production on Earth, and can be used to improve sustainable food production on Earth. |
| Funding Information: | |
| Additional Information: | Please see here: www.plants4space.com; this project can be conducted in collaboration with the German Space Agency, and or other international partners, please see web-address above for more details. |
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| University: | University of Adelaide |
| Faculty: | Faculty of Science, Engineering and Technology |
| Project Start Date: | 01.08.2023 |
| Application Deadline: | 30.06.2023 |
| Supervisor Name: | Matthew Denton, matthew.denton@adelaide.edu.au |
| Location (City/Campus): | North Terrace, Adelaide |
| Project Description: | We are looking to recruit a PhD student to work on this exciting, well-funded, project. The successful applicant will have scope to develop a project that focuses on plant physiology or molecular ecology and/or plant phenomics, in collaboration with supervisors. |
| Funding Information: | |
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| University: | University of Adelaide |
| Faculty: | Faculty of Science, Engineering and Technology |
| Project Start Date: | 01.08.2023 |
| Application Deadline: | 30.06.2023 |
| Supervisor Name: | Jamie Wood, jamie.wood@adelaide.edu.au |
| Location (City/Campus): | North Terrace, Adelaide |
| Project Description: | Pathogens are a large and crucial component of global biodiversity. However, changes in pathogen communities and populations caused by climate change have the potential to impact host health and disrupt global ecosystems. Our understanding of how climate change affects pathogens is poor, and lacks a long-term perspective. This project will look to use ancient DNA from animal dung and sediment cores to reconstruct how animal and plant pathogens responded to actual climate change events in the past. These unique ‘real-time’ insights into long-term processes will help answer pivotal questions in pathogen ecology and help inform modelling of emerging pathogen risks. |
| Funding Information: | |
Grundlegendes zum Schwerpunkt Bio- und Chemiewissenschaften
Im Mittelpunkt der Biologiewissenschaften stehen alle grundlegenden Aspekte lebender Organismen: Mikroorganismen, Pilze, Pflanzen und Tiere. Viele Forschungsgruppen arbeiten mit interdisziplinären Fragestellungen und untersuchen, wie Arten und Ökosysteme verwaltet, erhalten und wiederhergestellt werden können. Mit modernen Techniken und Methoden, die von molekularen und genetischen Analysen bis hin zu Big-Data-Sciences reichen, werden komplexe Zusammenhänge erforscht.
Wie die Biologie so spielt auch die Chemie in allen Bereichen unseres Lebens eine grundlegende Rolle. Zentrale Bedeutung hat die Entwicklung neuer Medikamente für die Behandlung von Krankheiten und die Entwicklung innovativer Materialien.Australische Hochschulen zeichnen sich durch hervorragende Grundlagen- und angewandte Forschung aus, deren Ergebnisse eine bedeutende Rolle für die chemische Industrie weltweit darstellen.
Deine Ansprechpartnerinnen im Bereich Forschung
Rebecca Fischer
Studienberatung & Bewerbungsabwicklung
Tel: +49 (0) 711 400 910 41
E-Mail: fischer[at]gostralia-gomerica.de
Svea Hellmig
Studienberatung & Bewerbungsabwicklung NRW
Tel: +49 (0) 221 975 868 70
E-Mail: hellmig[at]gostralia-gomerica.de